Program
Takahiro Ochiya, PhD
Project Professor
Division of Molecular and Cellular Medicine
Future Medicine Research Center
Institute of Medical Science
Tokyo Medical University
【Biography】
1988 Completed the doctoral program at the Graduate School of Medicine, Osaka University, and received a PhD in Medical Science.
1988 Research Assistant, Institute for Protein Research, Osaka University.
1991 Postdoctoral Fellow at a medical research institute in La Jolla, California, United States, now part of the Sanford Burnham Prebys Medical Discovery Institute.
1992 Principal Researcher, Molecular Oncology Division, National Cancer Center Research Institute.
1993 Head, Laboratory of Cellular Genetics, Molecular Oncology Division, National Cancer Center Research Institute.
1998 Head, Independent Laboratory for Cancer Metastasis Research, National Cancer Center Research Institute.
2010 Chief, Division of Molecular and Cellular Medicine, National Cancer Center Research Institute.
2018 Professor, Division of Molecular and Cellular Therapy, Institute of Medical Science, Tokyo Medical University.
2023 Project Professor, Division of Molecular and Cellular Therapy, Future Medicine Research Center, Institute of Medical Science, Tokyo Medical University.
Since 2019, Dr. Ochiya has been named a Highly Cited Researcher by Web of Science for seven consecutive years.
Extracellular Vesicle Therapeutics:
Clinical Translation and Future Prospects for Next-Generation Medicine
Lecture Abstract
Research on extracellular vesicles, including exosomes, has advanced rapidly in recent years, accelerating their clinical application in both diagnosis and treatment. In particular, the development of EV-based therapeutics has entered a period of intense global competition. In Japan, the first EV-based investigational product was administered to a patient in February 2026.
At the same time, important challenges are becoming increasingly apparent, including quality control, safety assessment, and the development of appropriate regulatory frameworks.
This session will review recent advances in EV research and current market trends, while also examining the present status and key challenges of EV-based therapies. Dr. Ochiya will conclude by exploring their future potential as a platform for next-generation medicine.
Makoto Nakanishi, MD, PhD
Project Professor
The Institute of Medical Science
The University of Tokyo
【Biography】
1985 Graduated from Nagoya City University School of Medicine.
1989 Completed the doctoral program at the Graduate School of Medical Sciences, Nagoya City University, and received a PhD in Medical Science.
1989 Research Associate, Department of Biochemistry, Jichi Medical University School of Medicine.
1992 Lecturer, Department of Biochemistry, Jichi Medical University School of Medicine.
From 1993 to 1995, he also served as a Research Associate in the Division of Molecular Virology at Baylor College of Medicine in the United States.
1997 Head, Geriatric Research Laboratory, National Center for Geriatrics and Gerontology.
1998 Associate Professor, Nagoya City University School of Medicine.
2000 Professor, Nagoya City University School of Medicine.
2016 Professor, Division of Cancer Defense Signaling, Department of Cancer and Cell Proliferation, The Institute of Medical Science, The University of Tokyo.
2019–2023 Deputy Director, The Institute of Medical Science, The University of Tokyo.
2023–2025 Director, The Institute of Medical Science, The University of Tokyo.
2026 Project Professor, Division of Cancer Defense Signaling, The Institute of Medical Science, The University of Tokyo.
2026 Project Professor, Department of Biology of Aging, Nagoya Advanced Research and Development Center, Nagoya City University.
Understanding Aging
Lecture Abstract
Even in an era of remarkable scientific and technological progress, the biological mechanisms of aging remain only partially understood.
Aging is also one of the most significant risk factors for a wide range of diseases, including cancer. If we can better understand the aging process—and develop ways to prevent or modify it—we may be able to reduce the risk of many age-related conditions. In this sense, understanding aging and intervening medically may represent the ultimate form of preventive medicine.
This lecture will review what is currently known about the molecular mechanisms of aging and explore whether aging can be prevented, slowed, or even reversed.
Toru Mizoguchi, MD
【Biography】
1990 Graduated from Fukushima Medical University School of Medicine.
1994 Resident, National Cardiovascular Center.
1995 Research Associate, Department of Anesthesiology, Yokohama City University School of Medicine.
2003 Founded Shinjuku Mizoguchi Clinic.
2014 Established Ortho-Molecular Nutrition Laboratory, Inc., and was appointed Representative Director.
2021 Opened Mizoguchi Clinic following its relocation from Shinjuku.
＜Edited Work＞
2003
Editor, The Latest Nutritional Science for Primary Care Physicians
Nanzando
＜Selected Publications＞
2001
Remarkable Nutritional Therapies Selected by a Physician
Bungeisha
2009
Depression Was Caused by Food
Seishun Publishing
2018
The Most Powerful Nutritional Therapy: An Introduction to Orthomolecular Medicine
Kobunsha
and other publications.
＜Supervised Translations＞
2016
Encyclopedia of Nutrition and Diet Therapy
GAIA BOOKS
2017
Foods That Heal and Foods That Harm: A Guide by Ingredient and Condition
Reader’s Digest
＜Awards＞
2018
Inducted into the Hall of Fame of the International Society for Orthomolecular Medicine.
Director, Mizoguchi Clinic
Medical Corporation Kaiseikai
Board Member,
The Japanese Society of Intravenous Therapy
Lecture Abstract
High-dose intravenous vitamin C therapy was introduced to a wider medical audience in Japan through Dr. Atsuo Yanagisawa’s 2007 book, Vitamin C Kills Cancer Cells. Today, it is used in cancer care at medical institutions across Japan.
A core principle of orthomolecular medicine is: “The tissue or organ with the highest demand for a nutrient is the first to suffer from its deficiency.”In the case of vitamin C, this may include the adrenal glands, white blood cells, the brain, and the skin.
This session will explore the clinical use of high-dose intravenous vitamin C not only in cancer care, but also in conditions involving these vitamin-C-dependent tissues and organs. Dr. Mizoguchi will also share practical approaches to orthomolecular nutritional therapy in clinical practice.
Hiromichi Matsumura, MD
【Biography】
Dr. Hiromichi Matsumura graduated from Nihon University School of Medicine.
He trained in the Department of Anesthesiology at Nihon University Itabashi Hospital and later worked in the Pain Clinic Department at Kanto Teishin Hospital, now NTT Medical Center Tokyo, as well as in the Departments of Anesthesiology and Psychiatry at Seishinkai Ujiie Hospital.
In October 2017, he was appointed Director of SPIC Clinic, now Kamakura Genki Clinic.
In his pursuit of holistic medicine, Dr. Matsumura has developed expertise in Eastern medicine, psychiatry, balneotherapy, orthomolecular medicine, and complementary and alternative medicine. He currently provides comprehensive care that integrates these disciplines, with a particular focus on stress management and preventive medicine.
Director
Kamakura Genki Clinic
Vice President
The Japanese Society of Intravenous Therapy
<Qualifications and Professional Appointments>
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Board-Certified Pain Clinic Specialist
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Certified Occupational Physician
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Board-Certified Balneotherapy Specialist
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Vice President, The Japanese Society of Intravenous Therapy
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President, Japanese Society for Medical and Environmental Ozone Therapy
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Chair, Clinical Research Division, Japanese Society for Medical and Environmental Ozone Therapy
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Board Member, Japan Orthomolecular Medical Association
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Member, ISCO3 Scientific Committee
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Advisor, Mental Wellness Training Association
<Publications>
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A Medical Approach to Resolving 90% of Frustrations in Personal Relationships
Mynavi Shinsho -
Preventing Disease through the Brain–Gut Axis
Shichisei Publishing
Glutathione Update 2027:
Beyond IV Therapy and into the Clinical Frontline
Lecture Abstract
In recent years, glutathione has emerged as far more than a simple antioxidant. It is now recognized as a multifaceted thiol system whose effects vary depending on the biological and clinical context.
This lecture will provide an updated overview of glutathione, with a focus on its practical use in intravenous therapy and key considerations for clinical implementation. It will also explore its differentiated applications in aesthetic medicine, its dual role in cancer therapy, the latest insights into neurodegenerative diseases, and its relationship to oxidative stress.
By bringing these perspectives together, the session will offer a more complete understanding of glutathione and its expanding role in clinical practice.
Atsuo Yanagisawa, MD, PhD
【Biography】
Dr. Atsuo Yanagisawa graduated from Kyorin University School of Medicine and completed his graduate studies at the same institution, earning a Doctor of Medical Science degree.
He later studied at Jefferson Medical College in the United States. After returning to Japan, he served as Associate Professor of Internal Medicine at Kyorin University School of Medicine and subsequently as Professor in the Department of Emergency Medical Science at the university’s School of Health Sciences.
Since 2008, he has served as Director of the International Center for Integrative Medicine Education. He also founded SPIC Salon Medical Clinic in Kamakura, Kanagawa Prefecture, now known as Kamakura Genki Clinic.
Dr. Yanagisawa is a U.S.-certified Chelation Therapy Specialist (CCT) and a Fellow of the American College of Cardiology (FACC).
President
The Japanese Society of Intravenous Therapy
Honorary Director
Kamakura Genki Clinic
2009
President, 10th International Congress of Integrative Medicine
2011
Inducted into the Hall of Fame of the International Society for Orthomolecular Medicine, Canada
2012–2023
President, International Society for Orthomolecular Medicine, Canada
2014
Received the Antoine Béchamp Award in France and the Pearl Maker Award in the United States, and was named an Outstanding Academician at the World Congress of Neural Therapy in Ecuador
2018
Chair, 47th Tokyo Congress of the International Society for Orthomolecular Medicine
2019
Founding President, Japanese Society for Orthomolecular Medicine
2020
Member, Scientific Advisory Board of Vitamin C for Covid, United Kingdom
2021
Honorary Member, Philippine Society for Orthomolecular Medicine
2024
Representative, Guardians for Health and Freedom
<Publications>
Dr. Yanagisawa is the author of numerous books, including:
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Vitamin C Kills Cancer Cells
Kadokawa SSC -
Treating Parkinson’s Disease with Intravenous Glutathione Therapy
GB -
Pain-Free Cancer Treatment with High-Dose Intravenous Vitamin C
GB -
Anti-Aging through Innovative Intravenous Therapy
Shufu no Tomo -
Overcoming COVID-19 with Vitamins C, D, and Zinc
Shufu no Tomo
Several of his books have also been translated and published internationally.
Medicine Reimagined:
Redefining the Future of Medicine for the Next Decade
Lecture Abstract
Over the past 20 years, the Japanese Society for Intravenous Therapy has explored new possibilities in medicine through the advancement of nutritional medicine, intravenous therapy, and integrative medicine.
This lecture will look back on the Society’s journey from “New Age Medicine” to “Liberal Medicine,” while also examining emerging medical concepts and technologies, including artificial intelligence, personalized medicine, preventive medicine, mitochondrial medicine, environmental medicine, and drug repositioning.
It will then consider the future direction of medicine.
The role of medicine is not limited to treating disease. It must also help maximize human health, potential, and quality of life.
Looking toward the next decade, this lecture will present a new vision for redefining medicine and healthcare.